Scientific Research

Scientific Research

Evidence-based technology backed by extensive clinical studies

Our Commitment to Science

At LUOVO, we believe in the power of scientific evidence. Every technology we incorporate into our products is backed by extensive research and clinical studies. We're committed to transparency about the science behind our products, enabling you to make informed decisions about your skincare routine.

Below, you'll find links to peer-reviewed research papers and clinical studies that demonstrate the efficacy and safety of the technologies we use, including LED Light Therapy, Photobiomodulation, Microcurrent Technology, High-Intensity Focused Ultrasound, Sonic Vibration, Thermal Therapy, Retinol, and Peptides.

Each of these technologies targets different skin concerns, from stimulating collagen production and improving skin elasticity to enhancing product penetration and reducing the appearance of fine lines and wrinkles. Our research not only focuses on effectiveness but also prioritizes safety to ensure our products meet the highest standards for home use.

Scientific Research

Our products are backed by extensive scientific research. Explore the studies below to learn more about the technologies we use.

Hyaluronic Acid for Dermal Hydration
National Institutes of Health - Research on HA providing dermal hydration and volume
Hyaluronic AcidTUS
Photobiomodulation and Skin Rejuvenation
National Institutes of Health - Low-level laser therapy for wound healing and skin rejuvenation
PhotobiomodulationLLLT
LED Red Light Therapy Effects on Skin Aging
National Institutes of Health - Research on efficacy of LED light therapy on skin rejuvenation
LED TherapyRed Light
Microfocused Ultrasound for Skin Tightening
Clinical Plastic Surgery - Comprehensive review of HIFU technology for skin rejuvenation
High-Intensity Focused UltrasoundSkin Tightening
Safety Study of Transcutaneous Focused Ultrasound for Non-Invasive Skin Tightening in Asians
Lasers in Surgery and Medicine - Clinical evaluation of HIFU safety and efficacy
High-Intensity Focused UltrasoundSkin Tightening
Noninvasive Skin Tightening: Focus on New Ultrasound Techniques
Clinical, Cosmetic and Investigational Dermatology - Review of ultrasound techniques for skin rejuvenation
High-Intensity Focused UltrasoundSkin Laxity
Microcurrent Technology for Facial Contouring and Skin Tightening
Journal of Clinical and Aesthetic Dermatology - Clinical study on microcurrent therapy efficacy
Microcurrent TechnologyFacial Contouring
Microcurrent Electrical Neuromuscular Stimulation Effect on Facial Aging
Journal of Cosmetic Dermatology - Evaluation of facial muscle tone improvement
Microcurrent TechnologyAnti-aging
Sonic Cleansing Brush Technology: Effects on Skin Permeability and Cleansing Efficacy
Dermatologic Surgery - Research on improved penetration of skincare products
Sonic VibrationCleansing Technology
Efficacy of Combined 633-nm and 830-nm Light-Emitting Diode Therapy
Journal of Cosmetic Laser Therapy - Research showing reduction in periorbital wrinkles
633nm LED830nm LEDMicro-Pulse PBM Technology
Photobiomodulation in Human Skin
Seminars in Cutaneous Medicine and Surgery - Research on cellular mechanisms of PBM in skin
PhotobiomodulationInfrared Light Therapy
Low-Level Laser Therapy for Fat Layer Reduction
Lasers in Surgery and Medicine - Clinical study on efficacy of 635-nm light therapy
LLLT635nm Light
Effects of Light-Emitting Diode Phototherapy on Skin Aging
Journal of Photochemistry and Photobiology - Research on skin rejuvenation and collagen increase
LED PhototherapyCollagen Production
Clinical Effects of Home-Use Light-Emitting Diode Device
Dermatologic Surgery - Study on home devices for wrinkle reduction
LEDHome DeviceAnti-aging
Thermal Therapy in Aesthetic and Dermatological Medicine
Journal of Cosmetic Dermatology - Comprehensive review of heat-based treatments
Thermal TherapySkin Rejuvenation
Sonic Technology in Skincare: Efficacy and Penetration Enhancement
Journal of Drugs in Dermatology - Research on sonic vibration for improved product delivery
Sonic VibrationProduct Penetration
Combination 830-nm and 633-nm LED Treatment for Periorbital Wrinkles
Journal of Clinical and Aesthetic Dermatology - Clinical improvements in skin complexion and intradermal collagen density
830nm LED633nm LEDPhototherapy
Red Light and Near-Infrared Radiation for Skin Rejuvenation
Photonics - Comprehensive review of mechanisms and applications
Red LightNear-InfraredSkin Rejuvenation
Evaluation of Microfocused Ultrasound for Lifting and Tightening Neck Laxity
Archives of Facial Plastic Surgery - Clinical study on HIFU efficacy for neck rejuvenation
High-Intensity Focused UltrasoundNeck Lifting
Clinical Pilot Study of Intense Ultrasound Therapy to Deep Dermal Facial Skin
Archives of Facial Plastic Surgery - Research on ultrasound effects on facial tissues
Intense UltrasoundFacial Rejuvenation
Effects of Thermal Stimulation on Collagen Production in Human Fibroblasts
Journal of Investigative Dermatology - Research on heat-mediated collagen synthesis
Thermal TherapyCollagen Production
Effects of Microcurrent Application on Hyaluronic Acid Production in Human Skin Fibroblasts
International Journal of Cosmetic Science - Research on microcurrent stimulation of HA
Microcurrent TechnologyHyaluronic Acid Production
Retinoids in the Treatment of Skin Aging
Clinical Interventions in Aging - Comprehensive review of retinoid efficacy on photoaged skin
RetinolAnti-aging
Improvement of Naturally Aged Skin with Vitamin A (Retinol)
Archives of Dermatology - Clinical study demonstrating retinol efficacy on fine wrinkles
RetinolCollagen Production
Retinol and Retinyl Esters: Biochemistry and Physiology
Journal of the American Academy of Dermatology - Mechanisms of action in skin
RetinolCellular Turnover
Clinical Efficacy of Self-applied Topical Peptides in Wrinkle Reduction
Journal of Cosmetic Dermatology - Clinical efficacy of various peptide formulations
PeptidesWrinkle Reduction
Role of Topical Peptides in Preventing or Treating Aged Skin
International Journal of Molecular Sciences - Comprehensive review of peptide mechanisms
PeptidesAnti-aging
Topical Peptide Treatments with Effective Anti-Aging Results
Cosmetics - Review of signaling, carrier, and neurotransmitter-affecting peptides
PeptidesSkin Rejuvenation
Retinol and Alpha-Hydroxy Acid Combination Treatments for Skin Aging
Journal of Cosmetic Dermatology - Synergistic effects of combined approaches
RetinolAHACombined Therapy
Efficacy of a New Topical Nano-hyaluronic Acid and Retinol in Facial Rejuvenation
Journal of Drugs in Dermatology - Clinical improvements in skin texture and wrinkles
RetinolHyaluronic AcidNanotechnology
Palmitoyl Pentapeptide-4 and Facial Wrinkles: Randomized Clinical Study
International Journal of Cosmetic Science - Effects on collagen synthesis and wrinkle depth
PeptidesCollagen Production
Safety Profile of LED Phototherapy
Journal of Clinical and Aesthetic Dermatology - Safety evaluation of LED devices for skin treatment
LED TherapySafety Study
Safety and Efficacy of Low-Level Light Therapy for Androgenetic Alopecia
Lasers in Surgery and Medicine - Long-term safety evaluation of photobiomodulation
LLLTPhotobiomodulationSafety Study
Safety Evaluation of Home-Use Microcurrent Devices
Journal of Cosmetic Dermatology - Clinical assessment of adverse events in microcurrent therapy
Microcurrent TechnologySafety Study
Safety and Tolerability of High-Intensity Focused Ultrasound for Noninvasive Body Sculpting
Dermatologic Surgery - Evaluation of side effects and safety considerations of HIFU
High-Intensity Focused UltrasoundSafety Study
Sonic Skin Cleansing Devices: Safety Profile and Epidermal Barrier Function Impact
Journal of the American Academy of Dermatology - Assessment of skin irritation and barrier disruption
Sonic VibrationSafety Study
Safety Assessment of Topical Retinoids
Cutaneous and Ocular Toxicology - Comprehensive review of retinoid safety data
RetinolSafety Study
Tolerability and Safety of Topical Peptides in Cosmetic Products
International Journal of Cosmetic Science - Review of peptide safety and irritation potential
PeptidesSafety Study
Safety and Clinical Efficacy of Thermal-Based Skin Treatments
Journal of Dermatological Treatment - Review of adverse effects and contraindications
Thermal TherapySafety Study
Safety of Non-Invasive Electrical Stimulation for Facial Rejuvenation
International Journal of Dermatology - Systematic review of safety outcomes
Microcurrent TechnologySafety Study
Cutaneous Safety of Hyaluronic Acid Formulations
Journal of Drugs in Dermatology - Evaluation of topical HA safety and biocompatibility
Hyaluronic AcidSafety Study
A Comprehensive Safety Review of Low-Level Laser Therapy
Photomedicine and Laser Surgery - Analysis of safety data from clinical trials
LLLTPhotobiomodulationSafety Study
Advanced Skin Cleansing Technologies: Comparison of Efficacy and Epidermal Barrier Impact
Journal of the American Academy of Dermatology - Evaluation of sonic cleansing devices
Sonic VibrationSkin Cleansing

Our Commitment to Safety

At LUOVO, safety is our top priority. We extensively research, test, and validate all our technologies and ingredients to ensure they meet the highest safety standards for home use.

Device Safety

All our devices undergo rigorous safety testing, including electrical safety certification, electromagnetic compatibility testing, and biocompatibility assessments. Our LED and laser technologies operate at safe energy levels with built-in safety mechanisms to prevent overexposure. Our ultrasound and microcurrent devices feature automatic shut-off protection and are designed to deliver precise energy levels appropriate for home use.

Ingredient Safety

Our serums and formulations are developed with safety in mind. We carefully select ingredients with established safety profiles and avoid known irritants and sensitizers. All formulations undergo dermatological testing for skin compatibility and are evaluated for potential irritation and allergic reactions. We use optimal concentrations of active ingredients like retinol and peptides to deliver results without compromising safety.

Clinical Validation

Before bringing any product to market, we conduct clinical studies to validate both efficacy and safety. Our studies monitor for any adverse reactions and assess long-term safety profiles. We maintain comprehensive documentation of all safety testing and regularly review emerging research to ensure our safety standards remain current with the latest scientific developments.

Individualized Safety Guidelines

We provide detailed safety guidelines and contraindications for each product, recognizing that individual skin sensitivities and medical conditions may affect suitability. Our customer support team is trained to provide personalized safety guidance, and we encourage consulting with a healthcare professional before using our devices if you have specific medical concerns or skin conditions.

Technology Highlights

LED Light Therapy

Our devices utilize specific wavelengths of light (633nm red light and 830nm near-infrared) to penetrate the skin at varying depths. Clinical studies have shown that these wavelengths stimulate cellular energy production, accelerate collagen synthesis, and reduce inflammation. The result is improved skin texture, reduced fine lines and wrinkles, and a more youthful appearance.

Microcurrent Technology

Microcurrent technology uses low-level electrical currents that mimic the body's natural electrical signals. Research shows these gentle currents can stimulate facial muscles, improve tone, and boost ATP production in skin cells. Regular use leads to visibly lifted contours, reduced sagging, and a more defined facial structure.

High-Intensity Focused Ultrasound

HIFU technology delivers focused ultrasound energy to the deeper layers of skin, precisely targeting the SMAS (Superficial Muscular Aponeurotic System) layer. This controlled thermal effect stimulates collagen production and tissue remodeling without damaging the skin's surface. Clinical studies demonstrate significant improvements in skin laxity, with effects that continue to improve over 2-3 months after treatment.

Sonic Vibration

Our sonic vibration technology utilizes high-frequency vibrations (up to 7,000 vibrations per minute) to deeply cleanse the skin and enhance product absorption. Research demonstrates that sonic cleansing is up to 6x more effective than manual cleansing, removing impurities, excess oil, and makeup residue while gently exfoliating. This technology also improves microcirculation and helps active ingredients penetrate more effectively.

Thermal Therapy

Controlled thermal energy stimulates collagen production by creating a mild, therapeutic heat stress in skin tissues. Studies show that this precise heating activates heat-shock proteins that protect cells and trigger repair mechanisms. Our thermal therapy technology maintains optimal temperatures (approximately 40-42°C) that are clinically proven to boost collagen synthesis without causing damage or discomfort.

Retinol

Our advanced retinol formulations harness the gold standard in anti-aging skincare. Clinical studies show that retinol accelerates skin cell turnover, stimulates collagen production, and improves elastin synthesis. This vitamin A derivative penetrates the epidermis and dermis to promote a more even skin tone, reduce fine lines and wrinkles, and improve overall skin texture. Our proprietary delivery system ensures optimal stability and minimizes irritation typically associated with retinol products.

Peptides

Our peptide technology utilizes specific amino acid sequences that act as cellular messengers in the skin. Research demonstrates that these biomimetic peptides can stimulate collagen synthesis, improve skin firmness, and reduce the appearance of expression lines. Different peptide types in our formulations target specific concerns: signal peptides stimulate collagen production, carrier peptides deliver trace elements for enzyme functions, and neurotransmitter-affecting peptides help relax facial muscles that cause expression lines.

Our Research Methodology

We adhere to rigorous scientific standards when evaluating technologies for our products:

Peer-Reviewed Research

We primarily rely on studies published in reputable, peer-reviewed scientific journals, ensuring the research has been evaluated by experts in the field.

Clinical Testing

We conduct and reference clinical studies that measure real-world results in human subjects, not just laboratory tests.

Long-Term Efficacy

We prioritize research that demonstrates sustained results over time, not just immediate effects that quickly fade.

Safety Profile

We carefully evaluate the safety profile of each technology, ensuring our products meet the highest standards for home use.

Our Scientific Advisory Board

Dr. Emily Wong

Dr. Emily Wong, Ph.D.

Dermatological Research

Dr. Wong has published over 30 papers on light therapy and skin rejuvenation technologies.

Dr. Michael Stevens

Dr. Michael Stevens, M.D.

Clinical Dermatology

With 20+ years of clinical practice, Dr. Stevens specializes in non-invasive skin rejuvenation techniques.

Dr. Sophia Rodriguez

Dr. Sophia Rodriguez, Ph.D.

Biophysics & Photobiology

Dr. Rodriguez is a leading researcher in the cellular mechanisms of photobiomodulation.

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